The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer DrugCambridge University Press, 5 бер. 2001 р. - 282 стор. Taxol is arguably the most celebrated, talked about, and controversial natural product in recent years. Celebrated because of its efficacy as an anticancer drug and because its discovery has provided powerful support for policies concerned with biodiversity. Talked about because in the early 1990s the American public was bombarded with news reports about the molecule and its host, the slow-growing Pacific yew tree. Controversial because the drug and the yew tree became embroiled in several sensitive political issues with broad public policy implications. Taxol has revolutionized the treatment options for patients with advanced forms of breast and ovarian cancers and some types of leukemia; it shows promise for treating AIDS-related Kaposi's sarcoma. It is the best-selling anticancer drug ever, with world sales of $1.2 billion in 1998 and expected to grow. Goodman and Walsh's careful study of how taxol was discovered, researched, and brought to market documents the complexities and conflicting interests in the ongoing process to find effective treatments. From a broader perspective, The Story of Taxol uses the discovery and development of taxol as a paradigm to address current issues in the history and sociology of science and medicine. Jordan Goodman is a Senior Lecturer in History at the Manchester School of Management, University of Manchester Institute of Science & Technology. He has written on subjects as varied as the history of medicine and economic history for journal articles and in edited volumes. Goodman's previous books include Tobacco in History (Routledge, 1994) and Consuming Habits: Drugs in History and Anthropology (Routledge, 1995). Vivien Walsh is Reader in Technology Management at the Manchester School of Management, University of Manchester Institute of Science & Technology. She has been researching the pharmaceutical and chemical industry for years and is currently working on globalization of innovative activity in the face of technological and organizational changes in the chemical, pharmaceutical, and agro-food industries. Walsh has been a consultant to the European Commission and to the Organisation for Economic Cooperation and Development. |
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Результати 6-10 із 40
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Зміст
Introduction | 3 |
Agents | 9 |
Cancer Chemotherapy Plant Knowledge and Practice | 11 |
Practices | 49 |
Act I 19621975 | 51 |
Act II 19761983 | 79 |
Act III 19841989 | 115 |
Controversies | 157 |
The Politics of Exclusivity and the Business of Taxol | 159 |
The Political Life and Death of Taxus brevifolia | 195 |
253 | |
282 | |
Інші видання - Показати все
The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug Jordan Goodman,Vivien Walsh Попередній перегляд недоступний - 2006 |
Загальні терміни та фрази
activity Advanced Molecular Technologies agents alkaloids American anti-cancer drug antitumor April Barclay biology Boettner Bristol-Myers Squibb Bureau of Land Camptothecin cancer chemotherapy cancer research Cancer Treatment CCNSC cell cent chemists chemotherapy clinical trials compounds Connolly contract December Destito Division of Cancer Douros Federal Forest Service harvesting Hauser Chemical Research Holton Horwitz industry Interview isolation Journal July laboratory Land Management Matthew Suffness maytansine Medicine microtubules molecule National Cancer Institute National Forest Native Yew Conservation Natural Products Branch NCI's needles November NPBII October old-growth forests ovarian cancer Pacific Northwest Pacific Yew paclitaxel patients pharmaceutical company Phase plant material plant screening programme Polysciences Potier pounds of bark problem Schepartz Science secondary metabolites semi-synthesis September Snader species Spjut spotted owl supply of taxol taxane taxol taxol and Taxus taxol content Taxus baccata Taxus brevifolia Taxus brevifolia bark timber total synthesis tumour University USDA Weyerhaeuser WLL1 yew bark
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