Mechanisms of Intracellular Trafficking and Processing of ProproteinsCRC Press, 23 жовт. 1992 р. - 320 стор. Mechanisms of Intracellular Trafficking and Processing of ProProteins provides an in-depth discussion of the cellular organization and current views of the molecular mechanisms underlying the trafficking, sorting, and processing of various classes of proproteins. The book covers the mechanisms of pro-protein translocation across the rough endoplasmic reticulum (RER) membrane and subsequent transport to the Golgi apparatus, molecular sorting and retention signals involved in directing pro-proteins to various cellular compartments, and the specific enzymes mediating different posttranslational modification steps. It is the only book that covers the principles of intracellular trafficking and processing of proproteins using examples representative of different classes of proproteins in the cell. New classes of enzymes, especially proteases with unique specificities, are examined as well. Mechanisms of Intracellular Trafficking and Processing of ProProteins presents a wealth of information valuable to cell biologists, endocrinologists, neurobiologists, enzymologists, and biochemists. Students studying molecular endocrinology, neurobiology, and cell biology will also find the book to be a useful text. |
Зміст
Chapter | 2 |
Sorting Mechanisms Signals and Receptors | 3 |
Concluding Remarks | 10 |
ISBN 0849368707 | 19 |
Protein Transport from the Endoplasmic Reticulum to | 79 |
Chapter 4 | 103 |
Chapter 5 | 131 |
Secretory Granule Formation | 157 |
Proteolytic Processing of Prohormones and ProNeuropeptides | 179 |
Chapter 8 | 200 |
Endoproteolysis of Growth Factors and Other Nonendocrine | 225 |
Chapter 9 | 251 |
Загальні терміни та фрази
6-P receptor Acad acid hydrolases activity aggregation amino acids AtT-20 cells basic amino acids basic residues binding Biochem biosynthesis bovine C-terminal C-trans carboxypeptidase cathepsin cDNA Cell Biol characterization Chem cleavage cleaved cloning compartment complex constitutive secretory encoding endoplasmic reticulum endoprotease function furin gene glycoprotein glycosylation Golgi apparatus growth factor GTP-binding proteins hormone hydrophobic identified insulin interactions intermediate intracellular involved KEX2 lysosomal enzymes mammalian mannose 6-phosphate mannose 6-phosphate receptor mature membrane proteins molecular monobasic mouse mutant nascent chain Natl newly synthesized oligosaccharides paired basic peptidase phosphorylated pituitary polypeptide POMC precursor Proc processing enzymes prohormone prohormone processing proinsulin propeptide proprotein protease protein translocation proteolytic purified regulated secretory proteins ribosome role secretion secretory granules secretory pathway secretory proteins secretory vesicles signal peptide signal sequence sorting specific ST sequences structure studies substrates subunits sulfation targeting terminus topogenic sequences topology transmembrane transport vitro yeast YPT1
Посилання на книгу
Encyclopedia of Molecular Biology and Molecular Medicine, Mass Spectrometry ... Robert A. Meyers Попередній перегляд недоступний - 1996 |