On arriving at the close of the first volume, the editors of the Chronicle would do injustice to their feelings, if they did not offer their grateful thanks for the flattering encouragement with which their labours have been received by their medical brethren. It is not to the extent of their subscription list that they now refer. From the local character and objects of their work, it was not to be supposed that this could ever have become very extensive, and the numerous and increasing facilities for perusing periodical works in our reading rooms, tend more especially to limit the purchase of this interesting class of publications. Notwithstanding these obstacles, we have every reason to congratulate ourselves on the support given to the work, and there is no doubt that if it should be continued another year, that it would prove even more profitable to the publishers. But it is not to this head we would invite the attention of our readers. It is to the decided approbation which has been expressed of the objects of our work, and of the manner in which they have been accomplished, an approbation not confined to a few individuals, but avowed by every independent man in the profession. To this we shall hereafter turn with grateful pride and satisfaction; regarding it as