The Anticancer Drugs

Передня обкладинка
Oxford University Press, 1994 - 352 стор.
This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer.

The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.
 

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Зміст

The Cancer Problem
3
Some Milestones in the Development of Cancer Chemotherapy
17
PART 3
45
Resistance to Anticancer Drugs
50
THE ANTICANCER DRUGS
63
Covalent DNA Binding Drugs
108
Noncovalent DNA Binding Drugs
155
Inhibitors of Chromatin Function
183
Drugs Affecting Endocrine Function
199
Choice of Drugs for Cancer Chemotherapy
235
Cancer Treatment
247
Anticancer Drug Development
265
Biological Treatments of Cancer
285
Potential Targets for New Anticancer Drugs
306
Index
337
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Про автора (1994)

William B. Pratt, Raymond W. Ruddon, William D. Ensminger, and Jonathan Maybaum are all at University of Michigan Medical School.

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