Trends in Monoclonal Antibody ResearchNova Publishers, 2005 - 148 стор. This new and important international source of information brings together leading-edge research dedicated to monoclonal antibodies. Monoclonal antibodies (MABs) are: antibodies of exceptional purity and specificity; components of the immune system; able to recognise and bind to a specific antigen. Monoclonal antibodies are currently utilised in many diagnostic procedures, including: measuring protein and drug levels in serum; typing tissue and blood; identifying infectious agents; identifying clusters of differentiation for the classification and follow-up therapy of leukaemias and lymphomas; identifying tumour antigens and auto-antibodies; identifying the specific cells involved in the immune response; identifying and quantifying hormones. For example, monoclonal antibodies (MABs or MOABs) work on cancer cells in the same way natural antibodies work, by identifying and binding to the target cells. They then alert other cells in the immune system to the presence of the cancer cells. MABs are specific for a particular antigen-one designed for a B-cell lymphoma will not work on cells for ovarian cancer cells for example. |
Зміст
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AntiAcetyllysine Antibody A Useful Tool for Listening to Posttranslational Language | 37 |
AntiCD20 Monoclonal Antibody in Kidney Transplantation | 59 |
Monoclonal Antibodies MAbs as Drug Delivery Systems PaclitaxelMAb Conjugates for Targeted Treatment of Cancer | 65 |
The Use of Monoclonal Antibodies in the Field of Pestivirology | 91 |
Oligopeptides as Tools for Improving Productivity of Hybridoma Cells Cultures | 111 |
Monoclonal Antibodies Specific to the HA2 gp of influenza A Virus Haemagglutinin | 123 |
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Загальні терміни та фрази
acetylation acetyllysine residue acetyllysine-containing affinity allosteric binding amino acid amino acid sequences anti-HA2 antibodies specific antigen antitumor apoptosis assay beads binding behavior Biol bovine viral diarrhea breast cancer cell line chelated Clin clinical complex concentration conjugate covalent CSFV cultures curves cytotoxicity detected diarrhea diarrhoea virus drug effect ELISA epitopes equilibrium binding equilibrium dissociation constant Fab fragments fluorescence Fraction of occupied Franěk free energy free energy changes genome glycoprotein HA2 gp HA2-specific MAbs haemagglutinin Herceptin heterotropic histone histone H3 homotropic positive cooperativity human hybridoma hybridoma cells immunization infection influenza virus inhibition isolates KinExA ligand membrane mice Microbiol molecule moles monoclonal antibodies mucosal disease myoglobin nonlinear regression nonlinear regression fit obtained occupied sites Oncol paclitaxel pan-reactive anti-acetyllysine antibodies peptides pestivirus protein G reactive rituximab shown site-specific soluble structure studies subtype targeted Taxol transplantation tumor vaccination Vareckova viral diarrhea virus Virol Virology viruses Zenon
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Сторінка 140 - Skehel, JJ, Bayley, PM, Brown, EB, Martin, SR. Waterfield, MD, White, JM, Wilson, IA...