Navelbine (vinorelbine): Update and New Trends

activity of Navelbine adenocarcinoma administered advanced breast cancer agents analysis antitumor activity axonal axonal microtubules breast cancer Cancer Treat Rep CDDP cell carcinoma cell lung cancer cisplatin combination chemotherapy compared concentrations cycles cyclophosphamide disease drug efficacy error rate etoposide evaluated Figure France grade group sequential methods hematologic toxicity Hexamethylmelamine histological included increase induced inoperable leukemia leukopenia lung cancer NSCLC MAP2 median survival metastatic mg/kg mg/m² mg/m²/week mice microtubules mitomycin molecule monotherapy Navelbine neuropathy neurotoxicity neutropenia nodes non-small cell lung number of patients objective response rate observed obtained Oncology ovarian P388 leukemia Paris Cedex partial responses performance status pharmacokinetics phase II study prognosis protocol radiotherapy randomized studies randomized trial regimens resected response duration small cell lung SPRT surgery Table Tau proteins therapeutic therapy tissue tolerance treatment Triangular Test tubulin tubulin aggregation tumor type I error values vinblastine vinca alkaloids vincristine vindesine vinorelbine weeks