New Drugs, Concepts and Results in Cancer Chemotherapy

Acad Sci USA acid acivicin administration Adriamycin agents analogs anthracycline antimetabolites antisense oligonucleotides ara-C Assoc Cancer Res binding Biochem Pharmacol biopsy breast cancer Cancer Treat carcinoma cardiac cardiotoxicity cell lines cellular chemotherapy Clin Oncol combination compounds concentrations CT and RT cyclophosphamide cytotoxicity daunorubicin DDATHF diastereomers dihydrofolate reductase dipyridamole dose doxorubicin drug effect enhanced enzyme estrogen receptor etanidazole factors folate FPGS free radicals g/m² GARFT gene glutathione growth homofolate hormone human hypoxic cells ICRF ifosfamide increase infusion inhibition inhibitor interaction ISBN lipid peroxidation mechanism meningioma meningioma specimens mesna metabolism methotrexate mg/m² mice microtubule misonidazole modulation Moran RG mouse mRNA Muggia myelosuppression Natl Acad Sci nitroimidazoles nucleoside oxazaphosphorine patients pharmacokinetics phase I study phosphorothioate plasma polyglutamates Proc Am Assoc Proc Natl Acad progesterone receptors protein radiation reduced reductase resistance schedule sensitivity specific substrate taxol therapeutic therapy thymidine thymidylate synthase tissue treatment tumor tumor cells uptake vitro vivo