New Drugs, Concepts and Results in Cancer Chemotherapy

Передня обкладинка
Franco M. Muggia
Springer Science & Business Media, 31 жовт. 1991 р. - 165 стор.
The decade of the 1990s will see an increasing emphasis on the modulation of chemotherapeutic drug selectivity and in the 'lock and key' approach to new targets to control malignant proliferation. The contents of this volume appropriately reflect these scientific undercurrents. An emerging powerful tool of molecular pharmacology is described by Holcenberg and Wu. Manipulation of genetic expression by modification of messenger RNA is now within our reach, and the basic concepts are suc­ cinctly reviewed as a primer on future biochemical engineering of new anti­ cancer molecules. Another concept that appears to be worthy of further study in both experimental and clinical chemotherapy concerns obs'ervations on the modulation of activity by the nucleoside transport inhibitor, dipyri­ damole. How potentiation of several anticancer drugs occurs has practical, as well as theoretical, ramifications, discussed by Goel and HowelL Finally, O'Dwyer and La Creta present a fresh look at sensitization of chemotherapy by the hypoxic radiosensitizer, SR-2731.
 

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Зміст

1 Pharmacologic control of specific gene expression
1
2 Modulation of the activity of cancer chemotherapeutic agents by dipyridamole
19
3 Pharmacology and clinical investigation of SR2508 etanidazole
45
4 Folate antimetabolites inhibitory to de novo purine synthesis
65
A new agent active in melanoma and ovarian cancer
89
Clinical and preclinical studies
101
7 Uroprotection in patients receiving cyclophosphamide and ifosfamide
119
8 The role of progesterone receptors in meningioma
127
9 Combined chemotherapy and radiotherapy in smallcell lung cancer
139
Addendum to Chapter 2
155
Index
157
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