New Drugs, Concepts and Results in Cancer ChemotherapyFranco M. Muggia Springer Science & Business Media, 31 жовт. 1991 р. - 165 стор. The decade of the 1990s will see an increasing emphasis on the modulation of chemotherapeutic drug selectivity and in the 'lock and key' approach to new targets to control malignant proliferation. The contents of this volume appropriately reflect these scientific undercurrents. An emerging powerful tool of molecular pharmacology is described by Holcenberg and Wu. Manipulation of genetic expression by modification of messenger RNA is now within our reach, and the basic concepts are suc cinctly reviewed as a primer on future biochemical engineering of new anti cancer molecules. Another concept that appears to be worthy of further study in both experimental and clinical chemotherapy concerns obs'ervations on the modulation of activity by the nucleoside transport inhibitor, dipyri damole. How potentiation of several anticancer drugs occurs has practical, as well as theoretical, ramifications, discussed by Goel and HowelL Finally, O'Dwyer and La Creta present a fresh look at sensitization of chemotherapy by the hypoxic radiosensitizer, SR-2731. |
Зміст
1 Pharmacologic control of specific gene expression | 1 |
2 Modulation of the activity of cancer chemotherapeutic agents by dipyridamole | 19 |
3 Pharmacology and clinical investigation of SR2508 etanidazole | 45 |
4 Folate antimetabolites inhibitory to de novo purine synthesis | 65 |
A new agent active in melanoma and ovarian cancer | 89 |
Clinical and preclinical studies | 101 |
7 Uroprotection in patients receiving cyclophosphamide and ifosfamide | 119 |
8 The role of progesterone receptors in meningioma | 127 |
9 Combined chemotherapy and radiotherapy in smallcell lung cancer | 139 |
Addendum to Chapter 2 | 155 |
157 | |
Інші видання - Показати все
New Drugs, Concepts and Results in Cancer Chemotherapy Franco M. Muggia Обмежений попередній перегляд - 2012 |
New Drugs, Concepts and Results in Cancer Chemotherapy Franco M. Muggia Попередній перегляд недоступний - 2012 |
New Drugs, Concepts and Results in Cancer Chemotherapy Franco M Muggia Попередній перегляд недоступний - 1991 |
Загальні терміни та фрази
Acad Sci USA acid acivicin administration Adriamycin agents analogs anthracycline antimetabolites antisense oligonucleotides Assoc Cancer Res binding Biochem Pharmacol biopsy breast cancer CANCER CHEMOTHERAPY Cancer Treat carcinoma cardiac cardiotoxicity cell lines cellular chemotherapy Clin Oncol combination compounds concentrations CT and RT cyclophosphamide cytotoxicity daunorubicin DDATHF diastereomers dipyridamole dose doxorubicin drug effect enhanced enzyme estrogen receptor etanidazole etoposide factors folate FPGS free radicals g/m² GARFT gene growth homofolate hormone human hypoxic cells ICRF ifosfamide increase infusion inhibition inhibitor interaction ISBN lipid peroxidation mechanism meningioma meningioma specimens mesna metabolism methotrexate mg/m² mice microtubule misonidazole modulation Moran RG mouse mRNA Muggia myelosuppression Natl Acad Sci nitroimidazoles nucleoside oxazaphosphorine patients pharmacokinetics phase I study phosphorothioate plasma polyglutamates potential Proc Am Assoc Proc Natl Acad progesterone receptors protein purine radiation reduced reductase resistance schedule sensitivity specific substrate taxol therapeutic therapy thymidine thymidylate synthase tissue treatment tumor tumor cells uptake vitro vivo