RNA EditingH. Ulrich Göringer Springer Science & Business Media, 12 січ. 2008 р. - 231 стор. “Editing a book on editing” has a certain “tongue in cheek” connotation to it, and I must admit that I was not aware what the job truly entailed when the project started. However, over the many months that it took to complete the book, it was interesting to realize that indeed “printing-type editing” and “biological editing” have many matching characteristics. Therefore, the quote by the well-known ? lm editor Verna Fields (1918–1982), “I wish the word “editing” had never been invented, “editing” implies correcting, and it’s not”, can function as a motto for the book: the various biological phenomena that are controlled by the different editing reactions are by far more complex than a simple correction process, and it is astounding how multifaceted the ? eld has become. All chapters of the book focus, as a general “editorial” subtext, on the corre- tion between RNA structure and function, and on complexity. This involves diff- ent length scales: from complex molecular machineries, to the interplay of complex biochemical pathways, and to evolutionary processes. The chapters are organized in a sequence beginning with a status quo account of RNA editing reactions from the focused perspective of RNA structure. This is followed by a chapter on the structure/function correlation in tRNA editing, and a chapter on RNA editing by adenosine deaminases that act on RNA (ADARs). |
Зміст
| 1 | |
Editing of tRNA for Structure and Function | 33 |
RNA Editing by Adenosine Deaminases that Act on RNA ADARs | 51 |
Michael F Jantsch and Marie Öhman | 85 |
Gott and Amy C Rhee | 105 |
RNA Editing in Chloroplasts | 123 |
the RNA Editing Machinery | 143 |
RNA Editing Accessory Factors the Example of mHel61p | 165 |
H Ulrich Göringer Michael Brecht Cordula Böhm and Elisabeth Kruse | 181 |
Evolutionary Aspects of RNA Editing 199 | 198 |
Masahiro Sugiura | 203 |
Index | 229 |
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Загальні терміни та фрази
activity ADAR ADAR1 ADAR2 addition adenosine affect alternative amino acid analysis associated bacteriophage base binding biochemical catalytic Cell changes chloroplast coding codon complex components conserved contains cytoplasm deaminase deamination deletion domain double-stranded duplex editing events editing sites editosome efficiency elements EMBO encoded enzyme essential et al expression extensive factors formation function gene genetic genome Gott gRNA human identified important indicate insertion interactions involved kinetoplastid lead ligase mechanism mitochondrial Mol Cell molecular molecules motifs mRNA multiple Nucleic Acids Res nucleotide observed occur organisms Physarum plant plant mitochondria position possible potential pre-mRNA protein reaction reading recently receptor recognition region regulate residues revealed RNA binding RNA editing RNAi role selection sequence showed shown similar Simpson single specific splicing steps structure Stuart studies substrate subunit suggesting template tobacco transcripts tRNA Trypanosoma brucei upstream vitro vivo
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Сторінка 223 - There is grandeur in this view of life, with its several powers, having been originally breathed by the Creator into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved.
Сторінка 33 - The difference between the right word and the almost right word is the difference between lightning and the lightning bug.
Сторінка 178 - Rigaut, G., Shevchenko, A., Rutz, B., Wilm, M., Mann, M., and Seraphin, B. (1999) A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 17, 1030-1032.
Сторінка 138 - Maliga, P. (1994) Introduction of a heterologous editing site into the tobacco plastid genome: the lack of RNA editing leads to a mutant phenotype. EMBO J., 13, 4623.
Сторінка 165 - Nature uses only the longest threads to weave her patterns, so each small piece of her fabric reveals the organization of the entire tapestry.
Сторінка 121 - Ohyama, K. (1992). Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA: A primitive form of plant mitochondrial genome. J. Mol. Biol. 223, 1-7.
Сторінка 1 - I do not believe in a personal God and I have never denied this but have expressed it clearly. If something is in me which can be called religious then it is the unbounded admiration for the structure of the world so far as our science can reveal it.
Сторінка 30 - Scott, J. (1987) A novel form of tissue-specific RNA processing produces apolipoproteinB48 in intestine. Cell 50, 831-840.