What Sustains Life?: Consilient Mechanisms for Protein-Based Machines and MaterialsSpringer Science & Business Media, 18 жовт. 2007 р. - 632 стор. In the sixth century BC, Thales of Miletus, father of the Ionian Enhghtenment, setting aside the mythic views of Homer and Hesiod asked, "What is the world made of?" and thereby became the first physicist.^ He answered that water is the basis of all matter and thereupon became an often cited example of early Greek reasoning gone astray. However, not only did Thales initi ate scientific inquiry, but also, with reference to living things, he was substantially correct. Living organisms are composed mostly of water, but the unique role of water in living organisms has been wanting for adequate description. From the perspective of D.H. Lawrence, "Water is H2O, hydrogen two parts, oxygen one part, but there is a third thing that makes it water and nobody knows what that is." From our perspective and as advanced in this volume, the interaction of water with dissimilar groups compris ing each protein molecule, the competition for water between these disparate substituents along chain molecules of living organisms, and the freedom of motion that water gives protein chains combine to provide the physical basis of Life. |
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Результати 1-5 із 92
Сторінка 9
... functional efficiency in designed elastic - contractile model proteins has been experimentally determined to be the competi- tion for water that occurs between oil - like domains and charged groups constrained to coexist within a ...
... functional efficiency in designed elastic - contractile model proteins has been experimentally determined to be the competi- tion for water that occurs between oil - like domains and charged groups constrained to coexist within a ...
Сторінка 16
... group . This lowers the cusp of insolubility along the tem- perature scale ... function by the consilient mech- anism of controlling phase separation . 1.2 ... group with releasable protons . • The positive charge disrupts hydrophobic as ...
... group . This lowers the cusp of insolubility along the tem- perature scale ... function by the consilient mech- anism of controlling phase separation . 1.2 ... group with releasable protons . • The positive charge disrupts hydrophobic as ...
Сторінка 18
... Function 1.2.3.6.1 When Assembled , the F1 - motor Functions as a Rotating Cusp ... group of ATP and the most super vinegar - like state of ADP plus P ; with ... functional F1 - motor . 1.2.3.7 Considered Steps in the F - motor Synthesis ...
... Function 1.2.3.6.1 When Assembled , the F1 - motor Functions as a Rotating Cusp ... group of ATP and the most super vinegar - like state of ADP plus P ; with ... functional F1 - motor . 1.2.3.7 Considered Steps in the F - motor Synthesis ...
Сторінка 21
... group on the surface of hemoglobin . • The resulting increase in oil hydration poises the hemoglobin molecules for ... function of positive cooperativ- ity , constituted the " second secret of life , " second only to " the structure of ...
... group on the surface of hemoglobin . • The resulting increase in oil hydration poises the hemoglobin molecules for ... function of positive cooperativ- ity , constituted the " second secret of life , " second only to " the structure of ...
Сторінка 29
... groups , distinguish the 20 naturally occurring amino acid residues . An R - group can be oil- like , containing only carbon and hydrogen , for example , -CH2CH ( CH3 ) 2 ; or the R - group can be vinegar - like , with a functional group ...
... groups , distinguish the 20 naturally occurring amino acid residues . An R - group can be oil- like , containing only carbon and hydrogen , for example , -CH2CH ( CH3 ) 2 ; or the R - group can be vinegar - like , with a functional group ...
Зміст
28 | |
Highlights | 70 |
On the Evolution of Proteinbased | 218 |
Biology Thrives Near a Movable | 239 |
Consilient Mechanisms for | 329 |
Epilogue | 541 |
Molecular | 574 |
Development of Elastic Proteinbased | 598 |
Index | 611 |
Інші видання - Показати все
What Sustains Life?: Consilient Mechanisms for Protein-Based Machines and ... Dan W. Urry Обмежений попередній перегляд - 2006 |
Загальні терміни та фрази
actin AGap AGHA amino acid amino acid residues apolar-polar repulsive free ATP synthase becomes biology carboxylate cell Chapter charged groups chemical energy competition for hydration Complex Complex III cross-bridge cross-linked curve cusp of insolubility cytochrome D.W. Urry dielectric dielectric relaxation dissociation efficient elastic protein-based polymers elastic-contractile model proteins Elastin electron energy conversion energy input energy of hydration entropy fibers filament formation functional group GEGFP Gibbs free energy globular GVGVP GVGFP heme hemoglobin hydrophobic association hydrophobic domains hydrophobic hydration increase interaction inverse temperature transition ion pairing kcal/mole matrix membrane model protein myosin occurs oil-like character oil-like domains oil-like groups oxidation oxygen peptide phase separation phosphate pKa shifts polar poly(GVGVP positive cooperativity positively charged Protein Data Bank protein-based machines proton R-group redox release repulsive free energy rotor sequence shown in Figure side chains solubility space-filling representation Stereo view Structure File subunit temperature interval tion tissue transduction y-rotor
Популярні уривки
Сторінка 218 - There is grandeur in this view of life, with its several powers, having been originally breathed by the Creator into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved.
Сторінка 70 - Population, when unchecked, increases in a geometrical ratio. Subsistence increases only in an arithmetical ratio.
Сторінка 70 - The race of plants and the race of animals shrink under this great restrictive law. And the race of man cannot, by any efforts of reason, escape from it.
Сторінка 70 - I think I may fairly make two postulata. First, That food is necessary to the existence of man. Secondly, That the passion between the sexes is necessary, and will remain nearly in its present state.
Сторінка 542 - ... other laws of physics' hitherto unknown, which, however, once they have been revealed, will form just as integral a part of this science as the former.
Сторінка 567 - We now Know that far from equilibrium, new types of structures may •originate spontaneously. In far-from-equilibrium conditions we may have transformation from disorder, from thermal chaos, into order. New dynamic states of matter may originate, states that reflect the interaction of a given system with its surroundings.
Сторінка 456 - No, a thousand times no; there does not exist a category of science to which one can give the name applied science. There are science and the applications of science, bound together as the fruit to the tree which bears it.
Сторінка 325 - HM Berman, J Westbrook, Z Feng, G Gilliland, TN Bhat, H Weissig, IN Shindyalov, and PE Bourne, The Protein Data Bank, Nucleic Acids Res.
Сторінка 131 - One of the principal objects of theoretical research in any department of knowledge is to find the point of view from which the subject appears in its greatest simplicity.
Сторінка 538 - The effects of morphine- and naloxone-like drugs in the non-dependent and morphine-dependent chronic spinal dog, J.
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Smart Polymers: Applications in Biotechnology and Biomedicine, Second Edition Igor Galaev,Bo Mattiasson Обмежений попередній перегляд - 2007 |