What Sustains Life?: Consilient Mechanisms for Protein-Based Machines and Materials
Springer Science & Business Media, 18 жовт. 2007 р. - 632 стор.
In the sixth century BC, Thales of Miletus, father of the Ionian Enhghtenment, setting aside the mythic views of Homer and Hesiod asked, "What is the world made of?" and thereby became the first physicist.^ He answered that water is the basis of all matter and thereupon became an often cited example of early Greek reasoning gone astray. However, not only did Thales initi ate scientific inquiry, but also, with reference to living things, he was substantially correct. Living organisms are composed mostly of water, but the unique role of water in living organisms has been wanting for adequate description. From the perspective of D.H. Lawrence, "Water is H2O, hydrogen two parts, oxygen one part, but there is a third thing that makes it water and nobody knows what that is." From our perspective and as advanced in this volume, the interaction of water with dissimilar groups compris ing each protein molecule, the competition for water between these disparate substituents along chain molecules of living organisms, and the freedom of motion that water gives protein chains combine to provide the physical basis of Life.
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The Pilgrimage Highlights in Our Understanding of the Products and Components of Living Organisms
Likelihood of Lifes Protein Machines Extravagant in Construction Yet Efficient in Function
Consilient Mechanisms for Diverse Proteinbased Machines The Efficient Comprehensive Hydrophobic Effect
On the Evolution of Proteinbased Machines Toward Complexity of Structure and Diversity of Function
Biology Thrives Near a Movable Cusp of Insolubility
Consilient Mechanisms for Proteinbased Machines of Biology
Advanced Materials for the Future Proteinbased Materials with Potential to Sustain Individual Health and Societal Development
Mechanics of Elastin Molecular Mechanism of Biological Elasticity and Its Relationship to Contraction
Development of Elastic Proteinbased Polymers as Materials for Acoustic Absorption
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actin AGHA amino acid amino acid residues apolar-polar repulsive free ATP synthase becomes biology biology’s carboxylate cell Chapter charged groups chemical energy competition for hydration Complex Complex III cross-bridge cross-linked curve cusp of insolubility D.W. Urry deﬁned dielectric relaxation dissociation efﬁciency elastic force elastic protein-based polymers elastic-contractile model proteins Elastin electron energy conversion energy input energy of hydration entropic elastic entropy ﬁber ﬁlament ﬁrst formation functional group Gibbs free energy globular GVGVP GVGFP heme hemoglobin hydrophobic association hydrophobic domains hydrophobic effect hydrophobic hydration increase interaction inverse temperature transition ion pairing membrane model protein motor myosin occurs oil-like domains oil-like groups oxidation oxygen peptide phosphate pKa shifts polar poly(GVGVP positive cooperativity positively charged Protein Data Bank protein-based machines proton R-group redox release repulsive free energy rotor sequence shown in Figure side chains signiﬁcant solubility speciﬁc Stereo view Structure File subunit sufﬁcient temperature interval tion tissue transduction y-rotor
Сторінка 218 - There is grandeur in this view of life, with its several powers, having been originally breathed by the Creator into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved.
Сторінка 70 - Population, when unchecked, increases in a geometrical ratio. Subsistence increases only in an arithmetical ratio.
Сторінка 70 - The race of plants and the race of animals shrink under this great restrictive law. And the race of man cannot, by any efforts of reason, escape from it.
Сторінка 70 - I think I may fairly make two postulata. First, That food is necessary to the existence of man. Secondly, That the passion between the sexes is necessary, and will remain nearly in its present state.
Сторінка 542 - ... other laws of physics' hitherto unknown, which, however, once they have been revealed, will form just as integral a part of this science as the former.
Сторінка 567 - We now Know that far from equilibrium, new types of structures may •originate spontaneously. In far-from-equilibrium conditions we may have transformation from disorder, from thermal chaos, into order. New dynamic states of matter may originate, states that reflect the interaction of a given system with its surroundings.
Сторінка 456 - No, a thousand times no; there does not exist a category of science to which one can give the name applied science. There are science and the applications of science, bound together as the fruit to the tree which bears it.
Сторінка 325 - HM Berman, J Westbrook, Z Feng, G Gilliland, TN Bhat, H Weissig, IN Shindyalov, and PE Bourne, The Protein Data Bank, Nucleic Acids Res.
Сторінка 131 - One of the principal objects of theoretical research in any department of knowledge is to find the point of view from which the subject appears in its greatest simplicity.
Сторінка 538 - The effects of morphine- and naloxone-like drugs in the non-dependent and morphine-dependent chronic spinal dog, J.