What Sustains Life?: Consilient Mechanisms for Protein-Based Machines and Materials

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Springer Science & Business Media, 18 жовт. 2007 р. - 632 стор.
In the sixth century BC, Thales of Miletus, father of the Ionian Enhghtenment, setting aside the mythic views of Homer and Hesiod asked, "What is the world made of?" and thereby became the first physicist.^ He answered that water is the basis of all matter and thereupon became an often cited example of early Greek reasoning gone astray. However, not only did Thales initi ate scientific inquiry, but also, with reference to living things, he was substantially correct. Living organisms are composed mostly of water, but the unique role of water in living organisms has been wanting for adequate description. From the perspective of D.H. Lawrence, "Water is H2O, hydrogen two parts, oxygen one part, but there is a third thing that makes it water and nobody knows what that is." From our perspective and as advanced in this volume, the interaction of water with dissimilar groups compris ing each protein molecule, the competition for water between these disparate substituents along chain molecules of living organisms, and the freedom of motion that water gives protein chains combine to provide the physical basis of Life.

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Зміст

Introduction
1
What Sustains Life? An Overview
28
The Pilgrimage Highlights in Our Understanding of the Products and Components of Living Organisms
70
Likelihood of Lifes Protein Machines Extravagant in Construction Yet Efficient in Function
94
Consilient Mechanisms for Diverse Proteinbased Machines The Efficient Comprehensive Hydrophobic Effect
102
On the Evolution of Proteinbased Machines Toward Complexity of Structure and Diversity of Function
218
Biology Thrives Near a Movable Cusp of Insolubility
239
Consilient Mechanisms for Proteinbased Machines of Biology
329
Advanced Materials for the Future Proteinbased Materials with Potential to Sustain Individual Health and Societal Development
455
Epilogue
541
Mechanics of Elastin Molecular Mechanism of Biological Elasticity and Its Relationship to Contraction
574
Development of Elastic Proteinbased Polymers as Materials for Acoustic Absorption
598
Index
611
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