Current Medicinal Chemistry |
Загальні терміни та фрази
acid agents amino analogues antagonists anti-androgens anticancer antiproliferative antitumor activity azatoxin Bentham Science Publishers bidirectional binding biological activity calcineurin cancer cell lines cell proliferation cellular clinical compounds Con-A Current Medicinal Chemistry cyclosporine cytotoxicity deoxypodophyllotoxin DNA breakage DNA topo drug E-ring effects enzyme epipodophyllotoxin ester evaluated fibrinogen glycosidic GPllb/llla H H H H3CO OCH3 HL-60/TPA system HNOC human hydroxyl group induced inhibitors inhibitory activity integrin KB cell kinase lactone leflunomide leukemia lignans mechanism of action Medicinal Chemistry MeO OMe microtubule Mizoribine modifications molecular molecule N-benzylphthalimide Naphthopyrans nt nt OCH3 OCH3 OH H oral pharmacophore picropodophyllotoxin podophyllotoxin podophyllotoxin derivatives podophyllum potent protein rapamycin receptor ring Scheme showed structure studies substitution synthesized T-cell Table tacrolimus teniposide teratogenicity thalidomide THP-1/OA systems THP-1/TPA and THP-1/OA TNF-a production TNF-a production-enhancing activity TNF-a production-inhibiting activities topo topo ll inhibition topoisomerase toxicity tubulin tubulin polymerization tumor vitro vitronectin vivo