Current Medicinal Chemistry |
Загальні терміни та фрази
1H NMR agonist amide protons amino acid amino-acid analogs aniline antagonist anticonvulsant anticonvulsant activity antiviral aqueous assigned backbone Bentham Science Publishers benzylamine biological activity BnO OBn BnOH2C Broad screening carbomethoxy carbon chemical shifts CLOGP compounds conformation correlation coupling constants cross-peaks Current Medicinal Chemistry cyclic derivative determined discovery distance constraints disulphide DMSO dynamics EETl-ll enaminone esters endothelin ester evaluation exchange H-bonding helix hydrogen bonding inactive indicated inhibitor interactions laboratory large number ligand lipophilicity lnhibits Medicinal Chemistry methods methyl mg/kg molecular molecule NMR data NMR spectra NOE data NOESY Non-Peptide Ligands nuclei observed opioid opioid receptor optimisation p-sheet parameters peptide peptide receptors peptide structure phenytoin potential protein protons pyrazofurin pyrazole quadrant random coil receptor binding relaxation residues resonances Scheme secondary structure shown in Fig sidechain simulated annealing solution solvent spectrum of TTR studies of peptides synthesis temperature torsion angle vitro