Cell Therapy: Stem Cell Transplantation, Gene Therapy, and Cellular ImmunotherapyGeorge Morstyn, William Sheridan Cambridge University Press, 29 бер. 1996 р. - 617 стор. Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer. |
Зміст
Effector Cells of Experimental and Clinical Cellular | 18 |
Current and Potential Uses of Defined Cell | 47 |
Flow Cytometric Techniques | 75 |
Principles of Gene Therapy | 91 |
Sources of Hemopoietic Progenitor Cells | 113 |
ChemotherapyBased Approaches to Mobilization | 130 |
CytokineOnly Approaches to Mobilization | 146 |
Characterization and Isolation of Mobilized | 183 |
Treatment of Solid Tumors with HighDose | 312 |
HighDose Chemotherapy with Cellular Support | 337 |
Allogeneic Marrow Transplantation as Treatment | 352 |
Clinical Gene Therapy | 369 |
Gene Therapy of Enzyme and Immune Deficiencies | 386 |
Cellular Therapy Approaches to the Treatment | 414 |
Adoptive Immunotherapy with T Cells | 429 |
Cellular Adoptive Immunotherapy with Natural | 451 |
Hemopoietic Stem Cell Selection Using Monoclonal | 199 |
Magnetic Approaches to Cell Separation | 213 |
Growth Factors and Ex Vivo Expansion | 221 |
Bioreactors for Expansion | 238 |
Purging of Malignant Cells | 250 |
DoseIntensive Chemotherapy without Hemopoietic | 269 |
Clinical Potential of Hemopoietic GrowthFactor | 299 |
Autologous Tumor Cell Vaccines | 475 |
Neutrophil Transfusions for Treatment of Infections | 510 |
Experimental and Clinical Cellular Immunotherapy | 527 |
Donor Lymphocyte Therapy in BoneMarrow | 550 |
GraftVersusLeukemia Effect in BoneMarrow | 568 |
587 | |
Загальні терміни та фрази
ABMT activity acute allogeneic allogeneic BMT allogeneic bone marrow antibody antigen antitumor assay autologous bone marrow blood progenitor cells blood stem cells bone marrow transplantation breast cancer CD34+ cells CD4+ CD8+ cell lines cellular Clinical Oncology culture cyclophosphamide cytokines cytotoxic donor doxorubicin engraftment etoposide ex vivo expression filgrastim G-CSF gene therapy gene transfer GM-CFC graft graft-versus-host disease granulocyte colony-stimulating factor granulocyte-macrophage growth factors GVHD hematological hematopoietic hemopoietic cells hemopoietic stem cells high-dose chemotherapy immune immunotherapy infection infusion interleukin-2 Journal of Clinical killer cells LAK cells leukapheresis long-term lymphocytes lymphoma malignant melanoma metastatic mg/m² mice mobilization molecules murine myeloid leukemia neutrophil NK cells Oncology PBPC peptides peripheral blood progenitor phase potential progenitor cells protein purging receptor recombinant human regimen relapse remission response retroviral vectors rHuG-CSF Shpall Slavin stem-cell studies survival T-cell target toxicity trans transduction transfusions treatment trials tumor cells tumor-specific viral virus vitro