The Anticancer DrugsOxford University Press, 1979 - 323 стор. "The strength of this book lies primarily in its superb organization and clarity, and in its accurate, up-to-date review of the information on each agent. The bibliographies are complete and current . . . . I reccomend this book highly." -- The New England Journal of Medicine "Excellent integration of the proposed mechanism of action of the agent, its uses against specific tumor types, and toxicity of the agent in humans... Few texts have achieved such a complete description of all major agents." -- Journal of Pharmaceutical Sciences. "Contain[s] a great deal of clinically useful information. In addition, it has an excellent discussion of the biochemical mechanism of action of each drug." -- Drug Intelligence and Clinical Pharmacy "One of the best written summaries of this type during the past two decades." -- Journal of Medicinal Chemistry |
Зміст
The Cancer Problem | 4 |
Some Milestones in the Development of Cancer Chemotherapy | 12 |
Determinants of Responsiveness to Anticancer Drugs | 20 |
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Загальні терміни та фрази
6-mercaptopurine A. C. Sartorelli actinomycin acute administration Adriamycin alkylating agents antibiotics anticancer drugs antitumor activity ara-C asparaginase assay binding Biochem Biol bleomycin Bone marrow depression breast cancer cancer chemotherapy Cancer Res carcinoma cell cycle chemotherapy clinical complex compounds concentration cross-linking cyclophosphamide Cytarabine cytotoxic D. G. Johns daunorubicin decreased dihydrofolate reductase disease DNA synthesis dose effect enzyme estrogen excretion FdUMP Figure Fluorouracil glucocorticoid Hodgkin's hormone human Hydroxyurea inhibition inhibitor injection intravenous leukemic cells levels liver lung lymphoma malignant mammalian cells mechanism of action mechlorethamine metabolism metabolites metastatic methotrexate mice microtubules Mithramycin mitomycin mouse nitrogen mustard nitrosoureas normal nucleic acid nucleotide occur Pharmacol pharmacology phase plasma platinum prednisone procarbazine produce prostate protein purine pyrimidine reaction receptor regimen remission renal resistance response sarcoma sensitive serum shown solid tumors steroid studies Table therapeutic therapy thymidylate synthetase tion tissue toxicity treat treatment tumor tumor cells vinblastine vinca alkaloids vincristine vitro vivo
Посилання на книгу
Textbook of Drug Design and Discovery, Third Edition Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen Обмежений попередній перегляд - 2002 |