TRAILElsevier, 6 лип. 2004 р. - 448 стор. The discovery of TRAIL (TNF Related Apoptosis Inducing Ligand), also referred to as Apo-2, is in an era of intense research because TRAIL induces many cancer cells to undergo programmed cell death (apoptosis), while having no effect on normal cells. This important protein deserves extensive review at a formative time in the devlopement of our knowledge concerning its mechanism of action and the ways in which it can be used as a cancer chemotherapeutic agent. Consequently, this voume reviews the current status of research on TRAIL. Selected Contents:* Crystal Structure of RANK Ligand involved in bone metabolism* Promoter of TRAIL-R2 Gene* Monoclonal Antibodies against TRAIL* Modulation of TRAIL signaling complex* TRAIL in the airways* FLIP Protein and TRAIL-Induced Apoptosis* TRAIL and Ceramide* TRAIL and Viral Infection* TRAIL and Malignant Glioma |
Зміст
| 19 | |
Chapter 3 Promoter of TRAILR2 Gene | 35 |
Chapter 4 Transcriptional Regulation of the TRAILR3 Gene | 51 |
Chapter 5 Monoclonal Antibodies Against TRAIL | 65 |
Chapter 6 Modulation of TRAIL Signaling Complex | 81 |
Chapter 7 TRAIL and NF kB SignalingA Complex Relationship | 101 |
Chapter 8 CARDINAL Roles in Apoptosis and NFkB Activation | 133 |
Chapter 9 TRAIL in the Airways | 149 |
Chapter 14 TRAIL and Viral Infection | 257 |
Chapter 15 Modulation of TRAIL Signaling for Cancer Therapy | 275 |
Chapter 16 InterferonGamma and TRAIL in Human Breast Tumor Cells | 291 |
Two Cooperating Actors to Fight Against Cancer | 319 |
Chapter 18 Potential for TRAIL as a Therapeutic Agent in Ovarian Cancer | 347 |
Chapter 19 TRAIL and Chemotherapeutic Drugs in Cancer Therapy | 365 |
Implications for Advances in Cancer Therapy | 385 |
Chapter 21 Regulation of Sensitivity to TRAIL by the PTEN Tumor Suppressor | 409 |
Chapter 10 TRAIL Death Receptors Bcl2 Protein Family and Endoplasmic Reticulum Calcium Pool | 169 |
Chapter 11 FLIP Protein and TRAILInduced Apoptosis | 189 |
Chapter 12 Epidermal Growth Factor and TRAIL Interactions in EpithelialDerived Cells | 207 |
Chapter 13 TRAIL and Ceramide | 229 |
Chapter 22 TRAIL and Malignant Glioma | 427 |
Chapter 23 Regulation of TRAILInduced Apoptosis by Ectopic Expression of Antiapoptotic Factors | 453 |
| 485 | |
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Загальні терміни та фрази
acid antiapoptotic antibodies antitumor Apo2L/TRAIL apoptosis-inducing ligand TRAIL apoptotic Ashkenazi Bcl-2 family Bcl-xL binding Biol breast cancer c-FLIP Ca2+ cancer cells Cancer Res carcinoma caspase caspase-8 cell death cell lines cellular ceramide Chem chemotherapeutic chemotherapy cleavage complex cytochrome cytokine cytotoxic DcR1 DcR2 death domain death receptor decoy receptors Degli-Esposti DR4 and DR5 drugs effector expression factor-related apoptosis-inducing ligand FADD FLIP gene glioma glioma cells growth factor human immune Immunol induces apoptosis inhibition inhibitor interaction interleukin-8 intracellular Krammer Marsters mechanisms mediated mice mitochondrial molecular molecules monoclonal antibodies necrosis factor-related apoptosis-inducing NF B activation NF-kappaB novel Oncogene Osteoprotegerin ovarian cancer overexpression Paclitaxel phosphorylation proapoptotic promoter protein kinase recruitment regulation resistance retinoid role sensitivity signaling pathways Smac/DIABLO sphingomyelinase therapy TNF family TRAIL receptors TRAIL-induced apoptosis TRAIL-R2 transcription factors Tschopp tumor cells tumor necrosis factor tumor necrosis factor-related upregulation vitro vivo Walczak Wang XIAP Zhang
Популярні уривки
Сторінка v - Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda, Maryland KENNETH V.
Сторінка 31 - WJ (2000). RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.